Glycyrrhetinic acid (GA) , a natural product from Glycyrrhiza glabra , found to be a novel mitochondria targeting ligand, is used to functionalize graphene oxide as an effective carrier for targeted delivery of doxorubicin into mitochondria. The GA-functionalized drug delivery system shows highly improved apoptosis induction ability and anticancer efficacy compared to the non-GA-functionalized nanocarrier delivery system. The GA-functionalized nanocarrier also shows low toxicity, suggesting that it can be a useful tool for drug delivery.
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